KEGG   REACTION: R01814
Entry
R01814                      Reaction                               
Name
L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)
Definition
Tetrahydrobiopterin + L-Tryptophan + Oxygen <=> 5-Hydroxy-L-tryptophan + Dihydrobiopterin + H2O
Equation
C00272 + C00078 + C00007 <=> C00643 + C00268 + C00001
Comment
two-step reaction (see R07213+R04734)
Reaction class
RC00023  C00268_C00272
RC00490  C00078_C00643
Enzyme
1.14.16.4
Pathway
rn00380  Tryptophan metabolism
rn01100  Metabolic pathways
Module
M00037  Melatonin biosynthesis, animals, tryptophan => serotonin => melatonin
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.16  With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.16.4
     R01814  Tetrahydrobiopterin + L-Tryptophan + Oxygen <=> 5-Hydroxy-L-tryptophan + Dihydrobiopterin + H2O
Orthology
K00502  tryptophan 5-monooxygenase [EC:1.14.16.4]

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Ontology (1)   
   KEGG BRITE (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG RCLASS (2)   
   SABIO-RK (1)   
Gene (1147)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1146)   
All databases (1163)   

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